|本期目录/Table of Contents|

[1]李春艳付志华刘星亮何燕燕.中年亚健康人群血清生化指标研究[J].山东体育科技,2012,01:0.
 LI Chun-yan,FU Zhi-hua,LIU Xing-liang,et al.Characteristics of serum biochemical indexes in middle-aged sub-healthy people[J].,2012,01:0.
点击复制

中年亚健康人群血清生化指标研究

《山东体育科技》[ISSN:1009-9840/CN:37-1011/G8]

期数:
2012年01期
页码:
0
栏目:
出版日期:
2012-02-25

文章信息/Info

Title:
Characteristics of serum biochemical indexes in middle-aged sub-healthy people
作者:
李春艳付志华刘星亮何燕燕
1.武汉体育学院健康科学学院,湖北 武汉430079;2. 武汉体育学院期刊社,湖北 武汉430079
Author(s):
LI Chun-yan1 FU Zhi-hua2 LIU Xing-liang1 HE Yan-yan1
1.College of Life Science, Wuhan Sports University, Wuhan 430079, China;2.Journals Press of Wuhan Sports University, Wuhan 430079, China
关键词:
中年亚健康血尿酸血脂血糖丙氨酸氨基转移酶天门冬氨酸氨基转移酶
Keywords:
middle-aged sub-healthy uric acid blood lipid glucoseALTAST
分类号:
G804.7
DOI:
-
文献标识码:
A
摘要:
目的:了解中年亚健康人群的血清生化指标特点。方法:以筛选出的中年(35~55岁)亚健康人群为研究对象(203例,其中男性131例,女性72例),以中年健康人群作为对照(40例,其中男性20例,女性20例),检测其空腹血尿酸(UA)、血糖(GLU)、血脂及肝功能相关的丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)等生化指标,并分析各生化指标的特点。结果:中年亚健康人群的UA、TC、TG、TC/HDL-C 和 LDL-C水平均显著高于健康对照组,且亚健康男性高于同年龄段的亚健康女性(P<0.05),HDL-C水平显著低于健康对照组,且亚健康男性低于同年龄段的亚健康女性(P<0.05);GLU水平均无显著性差异(P>0.05);亚健康男性的TG水平达1.86±0.94 mmol/L,明显高出正常血脂上限水平1.7 mmol/L,表现出边缘性升高;亚健康组与健康组的ALT、AST、ALT/AST等肝功能指标无显著性差异,但是亚健康男性的ALT、AST、ALT/AST和ALP显著高于亚健康女性;亚健康男性三个年龄段的UA水平均高于正常范围;随着年龄的增长,亚健康人群的TG及TC/ HDL-C水平均有增高的趋势,HDL-C则呈下降的走势。结论:中年亚健康男性的血尿酸和血脂等生化指标表现出异常的趋势。
Abstract:
The purpose of this study was to detect characteristics of serum biochemical indexes in middle-aged sub-healthy people. 203 middle-aged sub-healthy (131 of male and 72 of female) and 40 middle-aged healthy people(20 male and 20 female) participated in testing and analyzing serum biochemical indexes(serum uric acid-UA, blood lipid-TC,TG,HDL-C,LDL-C,glucose-GLU,ALT and AST). It was found that UA,TC,TG,TC/HDL-C and LDL-C were higher in sub-healthy than in healthy people,and higher in male than in female sub-healthy(P<0.05). HDL-C was lower in sub-healthy than in healthy people, and lower in male than in female sub-healthy(P<0.05). But no differences were found in GLU in all participants(P>0.05). It was noticeable that TG in male sub-healthy reached 1.86±0.94mmol/L, which overstepped 1.7mmol/L of upper limit in normal and manifested borderline increasing. And also ALT,AST,ALT/AST and ALT in male sub-healthy were higer than in female sub-healthy. The male sub-healthy UA were also gone beyond normal levels. With the growth of age, TG and TC/HDL-C in sub-healthy went up, and HDL-C went down. It could be seen that serum uric acid and blood lipid in male sub-healthy showed abnormity.

参考文献/References

[1]王育学.亚健康:21世纪健康新概念[M].南昌:江西科学技术出版社,2002:18.
[2]许景灿,任小红,李国安.我国职业人群心理亚健康状态的研究现状[J].中国现代护理杂志,2010,16(14):1734-1736.
[3]中国成人血脂异常防治指南制订联合委员会.中国成人血脂异常防治指南[J].中国心血管病杂志,2007,35(5):390-419.
[4]中华中医药学会.亚健康中医临床指南[M].北京:中国中医药出版社,2006:1-3.
[5]李保良,赵晓山,罗仁,等.亚健康疲劳状态血清对骨骼肌细胞蛋白质表达的影响[J].中国组织工程研究与临床康复,2009,13(11):2095-2100.
[6]赵晓山,罗仁,张曦倩,等.肾阴虚证cDNA文库的构建[J].中国现代医学杂志,2007,17(3):285-286.
[7]代方国,赵晓山,罗仁,等.构建中国汉族人亚健康状态肾阴虚证的DNA消减文库[J].中国临床康复,2005,9(19):97-99.
[8]孙晓敏,李晓勇,靳文,等.亚健康肾阴虚证的血浆蛋白质组学初步研究[J].四川中医,2008,26(4):7-9.
[9]Meeus M,Nijs J,McGregor N,et al.Unravelling intracellular immune dysfunctions in chronic fatigue syndrome:interactions between protein kinase R activity, RNase L cleavage and elastase activity and their clinical relevance[J].In Vivo, 2008, 22(11):115 -121.
[10]Maes M,Mihaylova I,Leuins JC.Increased serum lgM antibodies directed against phosphatidyl inositol(Pi) in chronic fatigue syndrome(CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression[J]. Neuro Endocrinol Lett, 2007,28 (6): 861-867.
[11]Mihaylova I,DeRuyter M,Rummens JL,et al.Decreased expression of CD69 in chronic fatigue syndrome in relation to inflammatory markers:evidence for a severe disorder in the early activation of T lymphocytes and natural killer cells[J].Neuro Endocrinol Lett, 2007,28(4):477-483.
[12]Richards RS,Wang L,Jelinek H. Erythrocyte oxidative damage in chronic fatigue syndrome[J].Arch Med Res, 2007,38(1):94-98.
[13]KelT JR,Petty R,Burke B,et al. Gene Expression Subtypes in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[J].J Infect Dis, 2008,197(8): 1171-1184.
[14]Maes M,Mihaylova I,Kubera M,el a1.Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome[J]. Neuro Endocrinol Lett, 2007,28(4):463-469.
[15]张庆富,周慧敏,白永强,等.亚健康人微循环紊乱及其临床意义[J].中国血液流变学杂志,2009,19(4):531-534.
[16]张庆富,周慧敏,白永强,等.亚健康红细胞流变学变化及几酮可可碱的治疗作用[J].中国血液流变学杂志,2009,19(2):195-198.
[17]张庆富,周慧敏,邵红波,等.亚健康血小板流变行为改变及几酮可可碱的治疗作用[J].中国血液流变学杂志,2009,19(3):366-368,499.
[18]Sundstro MJ,Sullivan LD,Agostion RB,et a1.Relations of serum uric acid to longtudinal blood pressure tracking and hypertention incidence [J]. Hypertention, 2005, 45(1):28-33.
[19]谭春梅,梁积英,高岩,等.肥胖与血压、血尿酸、血脂、血糖相关性研究[J]. 应用预防医学,2010,16(3):141-143,165.
[20]Price MJ, Shah PK. New strategies in managing and preventing stherosclerosis: focus on HDL[J].Rev Cardiovasc Med, 2002,3:129-37.
[21]Duffy D, Rader DJ.Emerging therapies targeting high-density lipoprotein metabolism and reverse cholesterol tran sport[J].Circulation,2006,113(8):1140-1150.
[22]von Eckardstein A, Hersberger M, Rohrer L. Current understanding of the metabolism and biological actions of HDL[J]. Curr Opin Clin Nutr Metab Care, 2005,8(2):147-52.
[23]National Cholesterol Education Program:Report of the Expert Panel on Detection,Evaluation and Treatment of High Blood Cholesterol in Aduhs Washington,DC,US Departmem of Health and Human Services[R].Public Health Services,National Institutes of Health,US Government Printing Office,234 -621 1/00222,78.
[24]张晓英.太极拳锻炼对老年健康状况的影响[J]. 体育科技文献通讯,2009,17(5):86-87.
[25]容春莉,彭应心,王秀萍,等.削弱高密度脂蛋白胆固醇心血管保护作用的影响因素分析[J].中国老年学杂志,2007,27(21):2101-2103.
[26]Kim JH,Lim YJ,Kim YH,et al.Is metabolic syndrome a risk factor for colorectal adenoma[J].Cancer Epidemiol Biomarkers Prev, 2007,16(8):1543-1546.
[27]Alsheikh-Ali AA,Maddukuri PV,Han H,et al.Effect of the magnitude of lipid lowering on risk of elevated liver enzymes,rhabdomyolysis,and cancer:insights from large randomized statin trials[J].J Am Coll Cardiol, 2007,50(5) [1]王育学.亚健康:21世纪健康新概念[M].南昌:江西科学技术出版社,2002:18.
[2]许景灿,任小红,李国安.我国职业人群心理亚健康状态的研究现状[J].中国现代护理杂志,2010,16(14):1734-1736.
[3]中国成人血脂异常防治指南制订联合委员会.中国成人血脂异常防治指南[J].中国心血管病杂志,2007,35(5):390-419.
[4]中华中医药学会.亚健康中医临床指南[M].北京:中国中医药出版社,2006:1-3.
[5]李保良,赵晓山,罗仁,等.亚健康疲劳状态血清对骨骼肌细胞蛋白质表达的影响[J].中国组织工程研究与临床康复,2009,13(11):2095-2100.
[6]赵晓山,罗仁,张曦倩,等.肾阴虚证cDNA文库的构建[J].中国现代医学杂志,2007,17(3):285-286.
[7]代方国,赵晓山,罗仁,等.构建中国汉族人亚健康状态肾阴虚证的DNA消减文库[J].中国临床康复,2005,9(19):97-99.
[8]孙晓敏,李晓勇,靳文,等.亚健康肾阴虚证的血浆蛋白质组学初步研究[J].四川中医,2008,26(4):7-9.
[9]Meeus M,Nijs J,McGregor N,et al.Unravelling intracellular immune dysfunctions in chronic fatigue syndrome:interactions between protein kinase R activity, RNase L cleavage and elastase activity and their clinical relevance[J].In Vivo, 2008, 22(11):115 -121.
[10]Maes M,Mihaylova I,Leuins JC.Increased serum lgM antibodies directed against phosphatidyl inositol(Pi) in chronic fatigue syndrome(CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression[J]. Neuro Endocrinol Lett, 2007,28 (6): 861-867.
[11]Mihaylova I,DeRuyter M,Rummens JL,et al.Decreased expression of CD69 in chronic fatigue syndrome in relation to inflammatory markers:evidence for a severe disorder in the early activation of T lymphocytes and natural killer cells[J].Neuro Endocrinol Lett, 2007,28(4):477-483.
[12]Richards RS,Wang L,Jelinek H. Erythrocyte oxidative damage in chronic fatigue syndrome[J].Arch Med Res, 2007,38(1):94-98.
[13]KelT JR,Petty R,Burke B,et al. Gene Expression Subtypes in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[J].J Infect Dis, 2008,197(8): 1171-1184.
[14]Maes M,Mihaylova I,Kubera M,el a1.Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome[J]. Neuro Endocrinol Lett, 2007,28(4):463-469.
[15]张庆富,周慧敏,白永强,等.亚健康人微循环紊乱及其临床意义[J].中国血液流变学杂志,2009,19(4):531-534.
[16]张庆富,周慧敏,白永强,等.亚健康红细胞流变学变化及几酮可可碱的治疗作用[J].中国血液流变学杂志,2009,19(2):195-198.
[17]张庆富,周慧敏,邵红波,等.亚健康血小板流变行为改变及几酮可可碱的治疗作用[J].中国血液流变学杂志,2009,19(3):366-368,499.
[18]Sundstro MJ,Sullivan LD,Agostion RB,et a1.Relations of serum uric acid to longtudinal blood pressure tracking and hypertention incidence [J]. Hypertention, 2005, 45(1):28-33.
[19]谭春梅,梁积英,高岩,等.肥胖与血压、血尿酸、血脂、血糖相关性研究[J]. 应用预防医学,2010,16(3):141-143,165.
[20]Price MJ, Shah PK. New strategies in managing and preventing stherosclerosis: focus on HDL[J].Rev Cardiovasc Med, 2002,3:129-37.
[21]Duffy D, Rader DJ.Emerging therapies targeting high-density lipoprotein metabolism and reverse cholesterol tran sport[J].Circulation,2006,113(8):1140-1150.
[22]von Eckardstein A, Hersberger M, Rohrer L. Current understanding of the metabolism and biological actions of HDL[J]. Curr Opin Clin Nutr Metab Care, 2005,8(2):147-52.
[23]National Cholesterol Education Program:Report of the Expert Panel on Detection,Evaluation and Treatment of High Blood Cholesterol in Aduhs Washington,DC,US Departmem of Health and Human Services[R].Public Health Services,National Institutes of Health,US Government Printing Office,234 -621 1/00222,78.
[24]张晓英.太极拳锻炼对老年健康状况的影响[J]. 体育科技文献通讯,2009,17(5):86-87.
[25]容春莉,彭应心,王秀萍,等.削弱高密度脂蛋白胆固醇心血管保护作用的影响因素分析[J].中国老年学杂志,2007,27(21):2101-2103.
[26]Kim JH,Lim YJ,Kim YH,et al.Is metabolic syndrome a risk factor for colorectal adenoma[J].Cancer Epidemiol Biomarkers Prev, 2007,16(8):1543-1546.
[27]Alsheikh-Ali AA,Maddukuri PV,Han H,et al.Effect of the magnitude of lipid lowering on risk of elevated liver enzymes,rhabdomyolysis,and cancer:insights from large randomized statin trials[J].J Am Coll Cardiol, 2007,50(5)

备注/Memo

备注/Memo:
湖北省“十二五”教育规划重点项目(2011A014),校博士科研启动项目
更新日期/Last Update: 2012-05-10