|本期目录/Table of Contents|

[1]孟昶,朱磊,田雪文,等.低氧运动与DNA甲基化的研究进展[J].山东体育科技,2019,05:0.
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低氧运动与DNA甲基化的研究进展

《山东体育科技》[ISSN:1009-9840/CN:37-1011/G8]

期数:
2019年05期
页码:
0
栏目:
出版日期:
2019-10-30

文章信息/Info

Title:
-
作者:
孟昶1朱磊1田雪文2王清路3
1.曲阜师范大学,山东 曲阜273165;2.山东体育学院,山东 济南250102;3. 齐鲁医药学院 山东省生物医学工程与技术重点实验室,山东 淄博255213
Author(s):
-
关键词:
低氧运动DNA甲基化亚硫酸氢盐测序
Keywords:
-
分类号:
G804.7
DOI:
-
文献标识码:
A
摘要:
DNA甲基化调控基因的表达,在肥胖和2型糖尿病等代谢类疾病的发病机制中起重要作用。针对 DNA 甲基化检测研究方法包括全基因组亚硫酸盐测序(BS-seq)、甲基化 DNA 免疫共沉淀测序(Me DIP-seq)和亚硫酸氢盐测序(RRBS)。研究表明低氧与EPAS1甲基化呈负相关,与LINE-1甲基化呈正相关,低氧运动可以使CpG和DMR甲基化显著。综述DNA甲基化分子机制及相关技术,探讨低氧运动与DNA甲基化的分子机制及生理学意义,展望低氧运动与DNA甲基化的研究前景,为防治代谢类疾病提供更多依据。
Abstract:
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参考文献/References

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备注/Memo

备注/Memo:
国家自然科学基金项目(项目编号:31701042);山东省重点研发计划《有氧运动和益生菌对肥胖青少年肠道微生物菌群结构影响》(项目编号:2017GSF18115)。
更新日期/Last Update: 1900-01-01